Jake Blues (John Belushi) is released from prison and, together with his brother Elwood (Dan Aykroyd), they receive a mission from God - they are to save the orphanage where they grew up. To earn money, they decide to reactivate their old band and give a concert. Unfortunately, something that sounds easy is not easy to do, especially when dealing with an ex-fiancee, Nazis from Illinois, the police or country musicians.